Custom Peptides
Cayman Chemical ContIntalIc AcId 10mg
A diterpenic acid with diverse biological activities; active against MSSA and clinical isolates of MRSA (MICs = 8 and 8-16 UG/ml, respectively); induces apoptosis in U-2932, OCI-LY1, and Ramos (RA 1) B cell lymphoma cells at 200 µM; improves renal function and decreases renal MDA and peroxidase levels, NO production, and neutrophil infiltration in a mouse model of E. coli- and LPS-induced renal injury
Cayman Chemical Phylnthn 10mg
A bioactive lignan component of P. amarus with antioxidative and hepatoprotective properties; scavenges DPPH radicals (IC50 = 7.4 µM) and alleviates carbon tetrachloride-induced lipid peroxidation and cytotoxicity in a human hepatoma HepG2 cell line
Cayman Chemical OmbrabulInhydrochlorIde 10mg
A tubulin polymerization inhibitor (IC50 = 11.3 µM) and tumor vascular disrupting agent; induces cell cycle arrest at the G2/M phase and apoptosis in HEY A8 and mouse mesenteric endothelial cells; reduces tumor growth and induces tumor necrosis in a HEY A8 mouse xenograft model at 30 mg/kg
Cayman Chemical TrnsportntrIfluoroacetate 10mg
A cell-penetrating peptide; has been used in the surface functionalization of liposomes for drug delivery in vitro and in vivo and for the delivery of fluorescent cargo in vitro
Cayman Chemical ML-309hydrochlorIde 10mg
An inhibitor of mutant IDH1; reversibly and selective inhibits IDH1R132H over wild-type IDH1 (IC50s = 96 and 36,500 nM, respectively); reduces 2-hydroxyglutarate production in U87 MG glioblastoma cells (EC50 = 55 nM)
Cayman Chemical SelonsertIb 10mg
An ASK1 inhibitor (IC50 = 5.01 nM); decreases apoptosis and stellate cell activation in an in vitro 3D-human liver microtissue model of palmitic acid-induced NASH at 1 µM; sensitizes KB-C2 ABCB1-expressing epidermoid carcinoma cells to doxorubicin and paclitaxel; reduces hepatic necrosis and increases in serum TNF-α, IL-6, and CCL2 in a mouse model of LPS/D-galactosamine-induced acute liver failure at 15, 30, or 60 mg/kg
Cayman Chemical N-desmethyl GalntamIn 10mg
An alkaloid and active metabolite of galantamine; inhibits AChE (IC50 = 0.23 µM) and ACh-induced currents by 64.8% in Xenopus oocytes expressing human α7 nAChRs at 100 µM; is cytotoxic to MOLT-4 cells and LMTK alveolar fibroblasts (IC50s = 0.6 and 0.5 UG/ml, respectively); decreases disease severity in a mouse model of carbon tetrachloride-induced acute liver injury at 1 and 10 mg/kg
Cayman Chemical ImepIphydrobromIde 10mg
A histamine H3 receptor agonist (KI = 0.4 nM in SK-N-MC cell membranes expressing the human receptor); selective for histamine H3 over H1 and H2 receptors in CHO cell membranes expressing the guinea pig and human receptors, respectively (Kis = >16 μM for both) but also agonizes H4 receptors (KI = 9 nM in SK-N-MC cell membranes expressing the human receptor); decreases hypothalamic histamine release in anesthetized rats at 5 mg/kg; decreases flinching in the formalin test in rats at 5 and 30 mg/kg and inhibits formalin-induced paw edema at 30 mg/kg
Cayman Chemical N3oxotetradecnoylLHomos 10mg
A small diffusible signaling molecule involved in quorum sensing, thereby controlling gene expression and affecting cellular metabolism in bacteria; appears later than shorter acyl chain AHLs in developing biofilms; stimulates the production of putisolvin, which in turn, inhibits biofilm formation
Cayman Chemical Ursocholic acid 10mg
A bile acid; dietary administration decreases gallbladder cholesterol, phospholipid, and bile acid levels and the occurrence of gallstones in male mice fed a lithogenic diet at 0.25%
Cayman Chemical SchIzndrIn B 10mg
A dibenzocyclooctadiene with diverse biological activities; completely inhibits anti-CD3- and anti-CD28-induced release of IL-2, IL-3, IL-4, IL-6, and IFN-γ in T cells at 50 μM; reduces cell survival and UV-induced phosphorylation of p53 and Chk1 from 1-30 μM; reduces ATR kinase activity (IC50 = 7.25 μM); inhibits doxorubicin-induced lipid peroxidation, formation of DNA strand breaks, and NADPH oxidase-dependent oxygen production in mouse heart from 25-100 mg/kg; reduces the expression of p53, 3-nitrotyrosine, phosphorylated p38 MAPK and MAPKAPK-2, and MMP-2 and MMP-9; reduces tert-butylhydroperoxide-induced mortality and malondialdehyde formation and increases GSH levels and GSH-Px activity in mouse brain.
Cayman Chemical ThymulInacetate hydrate 10mg
A peptide hormone; primarily produced by thymic epithelial cells; potentiates mitogen-induced proliferation of IL-2 receptor-positive mature T cells; has anti-inflammatory effects in various rodent models of inflammation; suppresses autoantibody production in a mouse model of reovirus-induced thyroiditis; prevents endotoxin-induced hyperalgesia in rats
Cayman Chemical StIrIpentol 10mg
An antiepileptic compound; positive allosteric modulator of GABAA receptors that potentiates GABA-mediated activation of α3 subunit-containing GABAA receptors; inhibits GABA reuptake in vitro and increases the release of GABA in neonatal rat hippocampal slices; inhibits LDH1 and LDH4 at 500 µM
Cayman Chemical NarcIsosIde 10mg
A flavonoid glycoside with antioxidative and antitumor activities; scavenges 27.74, 33.41, and 63% of DPPH radicals in a cell-free assay at 1, 10, and 100 µM, respectively; inhibits TPA-induced EBV-EA activation in Raji cells; inhibits TPA-induced papilloma formation in mice at 85 nmol